Heteronuclear transfers from labile protons in biomolecular NMR: Cross polarization, revisited
Physics
Improvement of heteronuclear transfers through J-driven cross polarization (J-CP), which transfers polarization by spin-locking the coupled spins under Hartmann-Hahn conditions. J-CP provides certain immunity against chemical exchange and other T2-like relaxation effects, a behavior that is examined in depth by both Liouville-space numerical and analytical derivations describing the transfer efficiency.
Figure: Numerical vs analytical solutions for J-CP as a function of contact time.
Ref: J. Magn. Reson., 333, 2021, 107083, Mihajlo Novakovic, Sundaresan Jayanthi, Adonis Lupulescu, Maria Grazia Concilio, Jihyun Kim, David Columbus, Ilya Kuprov, Lucio Frydman.